Can the Aero connect to smart home systems like Control4 or Home Assistant?
Not currently. The Manhattan Aero doesn’t have a public API for smart home systems like Control4, Crestron, Nice/Élan, or Home Assistant. This has been raised as a feature request with TiVo, who make the operating system the Aero runs on.
In the meantime, you can use HDMI-CEC to give your TV remote some control of the Aero, which can be enough for many use cases.